产品报价

￥800/2μg ￥2080/10μg ￥74880/1mg

背景资料

IL10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.

产品描述

人白介素-10重组蛋白是在大肠杆菌中重组表达的，由两条共价结合的多肽链组成；每条链包含有161个氨基酸，分子量为18606.29Da。该人白介素-10重组蛋白最终由标准的色谱技术纯化出。

来源宿主

大肠杆菌中重组表达

序列

The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Pro-Gly-Gln-Thr.

溶解建议

提供的人白介素-10(IL 10)产品为过滤灭菌的白色冻干粉末；该冻干粉末是从含1mg/ml人白介素-10(IL 10)的溶液（不含添加剂）中冻干产生的。我们建议加无菌的18MΩ-cm水以配制工作储存液到100μg/ml，后继实验过程中可根据实验要求进一步稀释。

保存建议

人白介素-10(IL 10)在室温可保存3周，或置于-18℃冻存用于长期保存。重新溶解后可以在4℃冷藏保存至少2-7天；如果想延长保存时间，建议分装（加载体蛋白如0.1% HSA或 BSA）后置于-18℃冻存。请避免反复冻融。