简介
The ZytoLight ® SPEC FGFR1/CEN 8 Pro-be is designed for the detection of FGFR1 gene amplification frequently observed in malignant tumors e.g. breast and prostate cancer and oral squamous cell carcinoma (OSCC).
The FGFR1 (fibroblast growth factor recep-tor 1) gene is located in the chromosomal region 8p12 and encodes a transmembra-ne receptor tyrosine kinase.Amplification of the FGFR1 gene, obser-ved in approximately 10% of all breast cancer samples, has revealed to be an independent prognostic factor for overall survival. FGFR1 is believed to emerge as a potential therapeutic target for lobular breast carcinomas.
In prostate cancer, FGFR1 gene amplifica-tion seems to be an important step during the transmission to hormone resistance. In OSCC, FGFR1 gene amplification, obser-ved in nearly 20% of all cases, is indica-ted to contribute to oral carcinogenesis at an early stage of development.
探针描述
The SPEC FGFR1/CEN 8 Probe is a mix-ture of an orange fluorochrome direct la-beled CEN 8 probe specific for the alpha satellite centromeric region of chromoso-me 8 (D8Z2) and a green fluorochrome direct labeled SPEC FGFR1 probe specific for the FGFR1 gene at 8p12.
结果
In a normal interphase nucleus, two oran-ge and two green signals are expected. In a cell with amplification of the FGFR1 gene locus, multiple copies of the green signal or green signal clusters wilved.
采购指南
联系电话：010-64484022、64484033，400-699-7909
Z-2072-200 ZytoLight SPEC FGFR1/CEN 8 Dual Color Probe 20 (200μl)
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Z-2028-20 ZytoLight FISH-Tissue Implementation Kit （20）
Incl. Heat Pretreatment Solution Citric, 500 ml; Pepsin Solution, 4 ml; Wash Buffer SSC, 500 ml; 25x Wash Buffer A, 100 ml; DAPI/Antifade-Solution, 0.8 ml
