简介
The ZytoLight ® SPEC EGFR/CEN 7 Dual Color Probe is designed for the detection of EGFR gene amplification frequently observed in solid neoplasms including non-small-cell lung cancer (NSCLC) and glioblastoma.
The EGFR gene (a.k.a. ERBB1 and HER1) is located in the chromosomal region 7p12 and encodes a transmembrane glycoprotein acting as a cellular growth factor receptor. The protein belongs to the EGFR (epidermal growth factor receptor) subgroup of the RTK (receptor tyrosine kinase) superfamily also including ERBB2 (HER2), ERBB3 (HER3), and ERBB4 (HER4).
Overexpression of EGFR has been shown in a number of tumor entities and is asso-ciated with poor prognosis. EGFR copy number identified by FISH is thought to be a molecular predictor in neoplasms.
探针描述
The SPEC EGFR/CEN 7 Dual Color Probe is a mixture of an orange fluorochrome direct labeled CEN 7 probe specific for the alpha satellite centromeric region of chromosome 7 (D7Z1) and a green fluoro-chr
结果
In a normal interphase nucleus, two oran-ge and two green signals are expected. In a cell with amplification of the EGFR gene locus, multiple copies of the green signal or green signal clusters will be observed.
采购指南
联系电话：010-64484022、64484033；400-699-7909
Z-2033-50 ZytoLight SPEC EGFR/CEN 7 Dual Color Probe 5 (50μl)
Z-2033-200 ZytoLight SPEC EGFR/CEN 7 Dual Color Probe 20 (200μl)
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Z-2028-5 ZytoLight FISH-Tissue Implementation Kit (5)
Incl. Heat Pretreatment Solution Citric, 150 ml; Pepsin Solution, 1 ml; Wash Buffer SSC, 150 ml; 25x Wash Buffer A, 50 ml; DAPI/Antifade-Solution, 0.2 ml
Z-2028-20 ZytoLight FISH-Tissue Implementation Kit (20)
Incl. Heat Pretreatment Solution Citric, 500 ml; Pepsin Solution, 4 ml; Wash Buffer SSC, 500 ml; 25x Wash Buffer A, 100 ml; DAPI/Antifade-Solution, 0.8 ml
