简介
The ZytoLight ® SPEC HER2/CEN 17 Dual Color Probe is designed for the detectionof HER2 gene amplification frequently observed in solid malignant neoplasms e.g. breast cancer samples.
The HER2 gene (a.k.a. ERBB2 and NEU) is located in the chromosomal region 17q12 and encodes a 185-190 kDa transmem-brane glycoprotein, p185, acting as a cellular growth factor receptor. The p185 protein belongs to the EGFR (epidermal growth factor receptor) subgroup of the RTK (receptor tyrosine kinase) superfami-ly also including ERBB1 (HER1), ERBB3 (HER3), and ERBB4 (HER4).
Amplification of the protooncogene HER2, observed in approximately 20% of all breast cancer samples, has been correla-ted with a poor prognosis of the disease. Similar results have been obtained for a variety of other malignant neoplasms e.g. ovarian cancer, stomach cancer, and carcinomas of the salivary gland.
探针描述
The SPEC HER2/CEN 17 Dual Color Probe is a mixture of an orange fluoro-chrome direct labeled CEN 17 probe specific for the alpha satellite centro-meric region of chromosome 17 (D17Z1) and a green fluorochrome direct labeled SPEC HER2 probe specific
结果
In a normal interphase nucleus, two oran-ge and two green signals are expected. In a cell with amplification of the HER2 gene locus, multiple copies of the green signal or green signal clusters will be observed.
采购指南：
联系电话：010-64484022、64484033；400-699-7909
Z-2015-50 ZytoLight SPEC HER2/CEN 17 Dual Color Probe 5 (50μl)
Z-2015-200 ZytoLight SPEC HER2/CEN 17 Dual Color Probe 20 (200μl)
相关产品
Z-2020-5 ZytoLight SPEC HER2/CEN 17 Dual Color Probe Kit (5)
Incl. Heat Pretreatment Solution Citric, 150 ml; Pepsin Solution, 1 ml; Wash Buffer SSC, 150 ml; Probe, 0.05 ml; 25x Wash Buffer A, 50 ml; DAPI/Antifade-Solution, 0.2 ml
Z-2020-20 ZytoLight SPEC HER2/CEN 17 Dual Color Probe Kit (20)
Incl. Heat Pretreatment Solution Citric, 500 ml; Pepsin Solution, 4 ml; Wash Buffer SSC, 500 ml; Probe, 0.2 ml; 25x Wash Buffer A, 100 ml; DAPI/Antifade-Solution, 0.8 ml
